Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biofabricated soft network composites for cartilage tissue engineering.

Onur Bas1, Elena M De-Juan-Pardo, Christoph Meinert

  • 1Institute of Health and Biomedical Innovation, Centre for Regenerative Medicine, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia.

Biofabrication
|April 5, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Matrix type influences embedded patient-derived osteosarcoma organoid invasion and response to treatment.

Frontiers in pharmacology·2026
Same author

Exploring the depth profile of low-pressure plasma-treated PDMS by VUV spectroscopic ellipsometry.

The Journal of chemical physics·2026
Same author

Catalytic oxygen generation and drug delivery via manganese dioxide nanoparticles to enhance radiotherapy in glioblastoma.

International journal of pharmaceutics·2026
Same author

Bottom-Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Conductive Hydrogels for Exogenous Sensing and Cell Fate Control.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

This study engineered cartilage tissue constructs using a novel hydrogel and fibrous network, mimicking native cartilage mechanics. These constructs show promise for regenerating load-bearing joint tissues.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Biomechanics

Background:

  • Articular cartilage is a complex composite crucial for joint function, exhibiting unique viscoelastic and stress relaxation properties.
  • Previous attempts using melt electrospinning of polycaprolactone (mPCL) for cartilage tissue engineering showed limitations under dynamic loading.
  • Improved material design is needed to effectively utilize reinforcing fibers in cartilage regeneration.

Purpose of the Study:

  • To develop advanced cartilage tissue-engineered constructs that emulate the mechanical properties of native articular cartilage.
  • To investigate the potential of a novel hydrogel matrix combined with fibrous networks for cartilage repair.
  • To establish a biomimetic system for studying cartilage mechanics and neocartilage formation.

Main Methods:

Related Experiment Videos

  • Fabrication of cartilage constructs using star-shaped poly(ethylene glycol)/heparin (sPEG/Hep) hydrogels and mPCL fibrous networks.
  • Characterization of mechanical properties, including anisotropy, nonlinearity, and viscoelasticity.
  • In vitro culture of human chondrocytes and assessment of neocartilage formation.
  • Development of a p-version of the finite element method (p-FEM) model for in silico analysis.

Main Results:

  • The sPEG/Hep hydrogel and mPCL fibrous network constructs demonstrated mechanical properties analogous to native cartilage.
  • The engineered constructs exhibited mechanical anisotropy, nonlinearity, and viscoelasticity.
  • A suitable microenvironment was provided for in vitro human chondrocyte culture and neocartilage formation.
  • The p-FEM model successfully predicted construct deformation and compressive moduli.

Conclusions:

  • This study presents the first cartilage tissue-engineered constructs that replicate the complex transient, equilibrium, and dynamic biomechanical properties of human articular cartilage.
  • The combination of sPEG/Hep hydrogels and mPCL fibrous networks offers a promising strategy for cartilage tissue engineering.
  • The developed biomimetic constructs and numerical model advance the field of cartilage repair and regenerative medicine.