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Ultrafast X-Ray Crystallography and Liquidography.

Hosung Ki1,2, Key Young Oang1,2, Jeongho Kim3

  • 1Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, South Korea; email: kihosung@kaist.ac.kr , wky3219@kaist.ac.kr , hyotcherl.ihee@kaist.ac.kr.

Annual Review of Physical Chemistry
|April 5, 2017
PubMed
Summary

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Time-resolved X-ray diffraction reveals molecular structures during reactions. This technique, applicable to crystals and solutions, now probes dynamics from picoseconds to femtoseconds using advanced X-ray sources.

Area of Science:

  • Chemical Physics
  • Structural Biology
  • Biophysics

Background:

  • Time-resolved X-ray diffraction offers direct insights into the three-dimensional structures of molecules during chemical and biological reactions.
  • Understanding reaction mechanisms requires detailed knowledge of transient structural changes.

Purpose of the Study:

  • To review the applications of time-resolved X-ray diffraction for studying molecular dynamics.
  • To highlight advancements in accessing faster timescales of reactions.

Main Methods:

  • Utilizing time-resolved X-ray diffraction on both crystalline (crystallography) and liquid-solution (liquidography) samples.
  • Employing synchrotron radiation for picosecond and slower dynamics.
  • Leveraging X-ray free-electron lasers for femtosecond dynamics.
Keywords:
X-ray free-electron laserserial femtosecond crystallographystructural dynamicstime-resolved X-ray crystallographytime-resolved X-ray diffractiontime-resolved X-ray liquidography

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Main Results:

  • Demonstration of time-resolved X-ray diffraction's capability to elucidate structural dynamics in chemical and biological processes.
  • Expansion of accessible timescales down to femtoseconds with new X-ray technologies.

Conclusions:

  • Time-resolved X-ray diffraction is a powerful tool for investigating reaction dynamics across various sample types.
  • Advances in X-ray sources significantly enhance the temporal resolution for studying ultrafast molecular motions.