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Related Experiment Video

Updated: Jul 12, 2026

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

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Published on: November 11, 2008

Recent Developments and Challenges in Optimization-Based Process Synthesis.

Qi Chen¹, I E Grossmann¹

¹Center for Advanced Process Decision Making, Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213;

Annual Review of Chemical and Biomolecular Engineering

|April 5, 2017

Summary

This review covers recent advancements and challenges in process synthesis and optimization-based conceptual design. It explores key concepts, methods, and future research directions for chemical process development.

Keywords:

conceptual design distillation sequences heat exchanger networks mathematical programming process flowsheets process synthesis reactor networks superstructures

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Area of Science:

Chemical Engineering
Process Systems Engineering

Background:

Process synthesis is crucial for designing efficient chemical processes.
Optimization-based conceptual design offers a systematic approach to process development.

Purpose of the Study:

To review recent developments and challenges in process synthesis.
To discuss key concepts in optimization-based conceptual design.
To provide a critical assessment and identify future research challenges.

Main Methods:

Literature review of process synthesis.
Review of optimization-based conceptual design concepts including superstructure representations, multilevel models, optimization methods, and modeling environments.
Synthesis of major subsystems and flowsheets.

Main Results:

Recent developments in process synthesis theory and practice are highlighted.
Key elements of optimization-based conceptual design are detailed.
A review of subsystem and flowsheet synthesis is presented.

Conclusions:

The article critically assesses the current state of process synthesis.
Future research challenges in process synthesis and optimization-based design are identified.