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Related Experiment Videos

Estriol: emerging clinical benefits.

Emad S Ali1, Cheyenne Mangold, Alan N Peiris

  • 11Department of Internal Medicine 2School of Medicine 3Section of Endocrinology, Texas Tech University Health Science Center, Lubbock, TX.

Menopause (New York, N.Y.)
|April 5, 2017
PubMed
Summary

Estriol, a pregnancy estrogen, shows promise for treating various conditions like menopausal symptoms and autoimmune diseases. Its immunomodulatory effects offer a potentially cost-effective therapeutic option for both women and men.

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Area of Science:

  • Endocrinology
  • Immunology
  • Women's Health

Background:

  • Estriol is the primary estrogen during pregnancy, known for its immunosuppressive effects on autoimmune diseases.
  • Emerging research highlights estriol's potential immunomodulatory benefits beyond gestation.

Purpose of the Study:

  • To review the emerging roles of estriol in treating various conditions, including menopausal symptoms, osteoporosis, cancer, hyperlipidemia, vascular disease, and multiple sclerosis.
  • To explore estriol's potential as a cost-effective therapeutic agent.

Main Methods:

  • A comprehensive review of English-language MEDLINE literature published between January 1974 and August 2016.
  • Focus on publications concerning nonpregnant females, with 72 articles referenced.

Main Results:

  • Estriol provides benefits for postmenopausal women, including improved menopausal symptom control and urogenital health, with reduced risks compared to traditional hormone therapies.
  • Its immunomodulatory role in reducing proinflammatory cytokines presents a therapeutic option for autoimmune and neurodegenerative conditions.
  • As a weak estrogen, estriol may be suitable for men, particularly for conditions like multiple sclerosis.

Conclusions:

  • Transvaginal estriol presents a physiologic and cost-effective alternative to existing estrogen regimens for selected patients.
  • Further research is warranted to investigate estriol's delivery methods, safety, and efficacy.

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