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Synthesis and Regulation of Thyroid Hormones01:20

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
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Related Experiment Video

Updated: Dec 28, 2025

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
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Recurrent thyrotoxicosis following near-total thyroidectomy.

Paul Gaschen1, Joehassin Cordero2, Alan N Peiris3

  • 1School of Medicine, Texas Tech University Health Sciences CenterLubbockTexas.

Proceedings (Baylor University. Medical Center)
|February 18, 2020
PubMed
Summary

Recurrent hyperthyroidism after total thyroidectomy is rare but possible. This case highlights the importance of monitoring for thyrotoxicosis recurrence even after near-total thyroid removal.

Keywords:
Graves’ diseaserecurrencethyrotoxicosistotal thyroidectomy

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Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Nuclear Medicine

Background:

  • Total thyroidectomy is a standard surgical procedure for managing hyperthyroidism, typically resulting in a cure.
  • Levothyroxine hormone replacement is initiated post-thyroidectomy to maintain euthyroid status.

Observation:

  • A 27-year-old woman presented with recurrent thyrotoxicosis approximately two years after a near-total thyroidectomy, despite levothyroxine therapy.
  • Diagnostic imaging revealed vascularized thyroid tissue in the right thyroid region with increased radioactive iodine uptake.

Findings:

  • The patient's recurrent hyperthyroidism was confirmed off levothyroxine therapy.
  • Ultrasound and radioactive iodine scan identified residual, functional thyroid tissue as the source of thyrotoxicosis.

Implications:

  • This case underscores the possibility of thyrotoxicosis recurrence after near-total thyroidectomy due to residual thyroid tissue.
  • It emphasizes the need for vigilant long-term monitoring of thyroid function in patients who have undergone thyroid surgery.
  • Management strategies may include antithyroid medication and radioactive iodine therapy for recurrent hyperthyroidism.