Cancer and the omics revolution.

Area of Science:

• Genomics and Molecular Oncology

Background:

• The field of internal medicine is rapidly evolving due to the 'omics revolution.
• Cancer medicine exemplifies this transformation, with molecular technologies impacting diagnosis, prognosis, and treatment.

Purpose of the Study:

• To present recent advances in gene-based cancer characterization.
• To illustrate these advances with clinical applications.

Main Methods:

• Review of molecular technologies for detecting gene alterations.
• Analysis of clinical applications in oncology.

Main Results:

• Gene-based characterization is increasingly influencing cancer care.
• Molecular insights are aiding in diagnosis, prognosis, and treatment selection.

Conclusions:

• Precision medicine, driven by omics data, is becoming a clinical reality.
• Limited therapeutic options for customization contrast with abundant omics data.
• Anticipated translational progress in the next decade for omics-driven cancer care.