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Remote Ischemic Conditioning in Elective PCI?

Joel P Giblett1, Stephen P Hoole1

  • 11 Department of Interventional Cardiology, Papworth Hospital, Papworth Everard, Cambridge, UK.

Journal of Cardiovascular Pharmacology and Therapeutics
|April 6, 2017
PubMed
Summary
This summary is machine-generated.

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Remote ischemic conditioning (RIC) may prevent heart damage during percutaneous coronary intervention (PCI). Following specific protocols is crucial for successfully translating RIC into clinical practice for patient benefit.

Area of Science:

  • Cardiology
  • Ischemia-Reperfusion Injury Research

Background:

  • Percutaneous coronary intervention (PCI) can cause ischemia-reperfusion injury.
  • Biomarker elevation post-PCI indicates this injury.

Purpose of the Study:

  • To review the rationale for using remote ischemic conditioning (RIC) in elective PCI.
  • To justify periprocedural biomarker elevation as a target for RIC.
  • To document rules for successful clinical translation of RIC.

Main Methods:

  • Literature review of remote ischemic conditioning (RIC) and percutaneous coronary intervention (PCI).
  • Analysis of evidence supporting RIC for preventing ischemia-reperfusion injury.
  • Identification of key factors for clinical implementation.
Keywords:
PCI-associated myocardial infarctionischemia–reperfusion injurypercutaneous coronary interventionremote ischemic conditioning

Related Experiment Videos

Main Results:

  • Remote ischemic conditioning (RIC) shows promise in mitigating PCI-induced injury.
  • Periprocedural biomarker elevation is a relevant target for RIC interventions.
  • Specific protocols are necessary for effective RIC application.

Conclusions:

  • Remote ischemic conditioning (RIC) is a potential strategy to reduce periprocedural myocardial injury during elective PCI.
  • Optimizing RIC protocols is essential for clinical success.
  • Further research and adherence to guidelines can facilitate RIC adoption.