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Related Concept Videos

Overview of Systemic Arteries01:11

Overview of Systemic Arteries

The human body is a complex, well-organized machine, and at the heart of its operations lies the circulatory system. This network of blood vessels, which includes systemic arteries, plays a vital role in maintaining life by transporting nutrients, oxygen, and waste products to and from cells throughout the body.
Systemic circulation is the part of the cardiovascular system that carries oxygenated blood away from the heart to the body's tissues and returns deoxygenated blood back to the heart.
Overview of Systemic Veins01:11

Overview of Systemic Veins

Systemic veins are crucial blood vessels that return deoxygenated blood from various body tissues back to the heart. There are three systemic veins that return deoxygenated blood to the heart, they are as follows.
The coronary sinus, the heart's principal vein, resides in the coronary sulcus on the heart's posterior aspect. This broad venous channel receives nearly all venous blood from the myocardium, the heart muscle. It is fed by three primary veins: the great cardiac vein, the middle...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...

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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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Published on: February 8, 2019

Update on systemic vasculitides.

Siddiq Anwar1, M Yousuf Karim2

  • 1Department of Medicine, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.

Journal of Clinical Pathology
|April 6, 2017
PubMed
Summary
This summary is machine-generated.

Systemic vasculitis management has improved with targeted biological agents. Optimal use of these costly treatments is crucial for remission, relapse prevention, and improved quality of life.

Keywords:
ANTIBODIESAUTOANTIBODYIMMUNOLOGYLYMPHOCYTESVASCULITIS

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Area of Science:

  • Rheumatology and Immunology
  • Internal Medicine

Background:

  • Systemic vasculitis management has been transformed by targeted biological agents.
  • Increased prevalence and recognition of vasculitis necessitate optimal treatment utilization.
  • High costs of biological agents require careful consideration for effective patient outcomes.

Purpose of the Study:

  • To review recent advances in the diagnosis of systemic vasculitis.
  • To discuss current surveillance strategies for vasculitis patients.
  • To highlight novel treatment approaches for systemic vasculitis.

Main Methods:

  • Literature review of recent advancements in vasculitis diagnosis.
  • Analysis of current surveillance techniques for managing vasculitis.
  • Synthesis of data on emerging biological agents and therapeutic strategies.

Main Results:

  • Biological agents have significantly improved vasculitis management outcomes.
  • Optimal utilization strategies are key to maximizing treatment benefits.
  • Advances in diagnosis and surveillance aid in early detection and monitoring.

Conclusions:

  • Targeted biological agents represent a major advancement in systemic vasculitis therapy.
  • Effective management requires a focus on achieving and maintaining remission while minimizing toxicity.
  • Ongoing research into diagnosis, surveillance, and treatment is vital for improving patient quality of life and reducing mortality.