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Quinazolyl benzophenothiazines as potential antiviral agents
V K Pandey1, D Misra, M N Joshi
1Department of Chemistry, University of Lucknow, India.
Pharmacological Research Communications
|February 1, 1988
Summary
Researchers synthesized novel benzophenothiazine compounds. Two of these synthesized compounds demonstrated significant antiviral activity, inhibiting virus multiplication effectively.
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
- Virology
Background:
- Benzoxazine and quinazoline derivatives are known for their diverse biological activities.
- Benzophenothiazines represent a class of heterocyclic compounds with potential therapeutic applications.
Purpose of the Study:
- To synthesize a series of novel benzophenothiazine derivatives.
- To evaluate the synthesized compounds for their antiviral activity.
Main Methods:
- Multi-step organic synthesis starting from anthranilic acid and benzoyl chloride.
- Condensation reactions involving intermediates like 2-phenyl(3H) 4-oxo-3,1-benzoxazine and 2-phenyl-3-hydroxy-ethyl(3H) 4-oxo-quinazoline.
- Cyclization reactions using sulfur and iodine to form the benzophenothiazine core.
- In vitro screening for antiviral activity against selected viruses.
Main Results:
- Five novel benzophenothiazine derivatives were successfully synthesized.
- Two of the synthesized compounds exhibited significant inhibition of virus multiplication.
- The structure-activity relationship of these compounds warrants further investigation.
Conclusions:
- The synthesized benzophenothiazine derivatives show promise as antiviral agents.
- Further research is needed to optimize these compounds for therapeutic use.
- This study contributes to the development of new antiviral drug candidates.