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[Hyperthermia in bone and soft tissue tumors].

Y Kajiura1, I Tsukiyama, T Ogino

  • 1Dept. of Radiation Therapy, National Cancer Center.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|April 1, 1988
PubMed
Summary

Hyperthermia effectively treats superficial soft tissue and bone tumors, achieving a 60% response rate. Deep-seated tumors showed a lower response, indicating hyperthermia is more beneficial for superficial cancers.

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Area of Science:

  • Oncology
  • Medical Physics
  • Radiology

Context:

  • Soft tissue and bone tumors present diverse treatment challenges.
  • Hyperthermia is an emerging therapeutic modality for various cancers.
  • Evaluating treatment efficacy requires understanding tumor location and type.

Purpose:

  • To investigate the local response of hyperthermia in treating soft tissue and bone tumors.
  • To compare the efficacy of hyperthermia based on tumor depth (superficial vs. deep-seated).
  • To analyze tumor response through clinical outcomes and histological examinations.

Summary:

  • This study evaluated hyperthermia's local response in 26 soft tissue and bone tumors (10 superficial, 16 deep-seated).
  • Superficial tumors showed a 60% response rate (4 complete, 2 partial). Deep-seated tumors had an 81.4% response rate (1 complete, 3 partial), with necrosis observed in non-responding deep tumors.

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  • Hyperthermia combined with radiation therapy or arterial infusion of ADR was employed.

    • Impact:

    • Hyperthermia demonstrates significant local response rates, particularly for superficial soft tissue and bone tumors.
    • Histological and CT examinations confirm tumor response, including coagulation necrosis.
    • Findings suggest hyperthermia as a valuable treatment option, especially for accessible tumors.