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Updated: Aug 26, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
Published on: May 22, 2014
A Novel Protective Role for FXR against Inflammasome Activation and Endotoxemia
Oihane Garcia-Irigoyen1, Antonio Moschetta1
1Department of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy; INBB, National Institute for Biostructures and Biosystems, 00136 Rome, Italy; National Cancer Research Center, IRCCS Istituto Oncologico "Giovanni Paolo II," 70124 Bari, Italy.
Abstract:
During conditions of impaired bile flow (cholestasis), increased serum bile acids (BAs) are prognostic markers of sepsis. In this issue, Hao et al. (2017) show that the BA receptor FXR binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome components, thus reducing endotoxemia in cholestasis.
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