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Genetic Polymorphisms in Organic Cation Transporter 1 Attenuates Hepatic Metformin Exposure in Humans

Eio Sundelin1, L C Gormsen2, J B Jensen1,2

  • 1Research Laboratory for Biochemical Pathology, Department of Clinical Medicine, Aarhus University Hospital, Denmark.

Clinical Pharmacology and Therapeutics
|April 6, 2017
PubMed
Summary

Genetic variations in the OCT1 transporter affect how much metformin reaches the liver in type 2 diabetes patients. This impacts drug efficacy and highlights the use of imaging in pharmacogenetics.

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