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Related Experiment Videos

Nanoplasmonic sensors for biointerfacial science.

Joshua A Jackman1, Abdul Rahim Ferhan, Nam-Joon Cho

  • 1School of Materials Science and Engineering, Nanyang Technological University, Singapore, 639798, Singapore. njcho@ntu.edu.sg.

Chemical Society Reviews
|April 7, 2017
PubMed
Summary

Nanoplasmonic sensors offer label-free detection of biomolecules for medical and environmental applications. Surface-based sensors provide enhanced, quantitative measurements of biomacromolecules, viruses, and exosomes at interfaces.

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Area of Science:

  • Biointerfacial Sciences
  • Nanotechnology
  • Biomedical Sensing

Background:

  • Nanoplasmonic sensors enable label-free detection of biomolecules, with applications in medicine, biotechnology, and environmental science.
  • Surface-based nanoplasmonic sensors are emerging as powerful tools for quantitative measurements of biomacromolecules and biological particulates.

Purpose of the Study:

  • To review recent advances in nanoplasmonic sensors for biointerfacial sciences.
  • To highlight the development of nanoparticle and nanohole arrays for studying biomacromolecule interactions at solid-liquid interfaces.
  • To explore applications in protein binding, lipid membranes, exosome/virus detection, and nucleic acid interactions.

Main Methods:

  • Introduction to measurement principles: localized surface plasmon resonance (LSPR) and extraordinary optical transmission (EOT).

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  • Categorization of applications by biological themes: protein binding, lipid membranes, membrane-protein interactions, exosome/virus detection, and nucleic acid interactions.
  • Discussion of advanced measurement capabilities: positional sensing, conformational analysis, and real-time kinetic monitoring.

    • Main Results:

    • Nanoplasmonic sensors demonstrate high surface sensitivity suitable for medically important biomacromolecules and particulates.
    • Advanced measurement capabilities enable detailed analysis of complex biological interactions at interfaces.
    • Ongoing development of commercial sensors and analytical models facilitates broader application.

    Conclusions:

    • Nanoplasmonic sensors offer significant potential for fundamental biointerfacial science research.
    • These technologies are poised for translational applications in clinical medicine and pharmaceutical drug development.
    • The field shows strong growth prospects with continued innovation in sensor design and data interpretation.