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Spread spectrum time-resolved diffuse optical measurement system for enhanced sensitivity in detecting human brain

Kalpesh Mehta1, Ali Hasnain1, Xiaowei Zhou1

  • 1National University of Singapore, Department of Biomedical Engineering, Singapore, Singapore.

Journal of Biomedical Optics
|April 7, 2017
PubMed
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We developed a low-cost, portable diffuse optical spectroscopy (DOS) system for real-time brain activity detection. Utilizing late-arriving photons significantly improved sensitivity for cortical neural activity monitoring.

Area of Science:

  • Neuroscience
  • Biomedical Optics
  • Medical Instrumentation

Background:

  • Diffuse optical spectroscopy (DOS) and imaging are established noninvasive techniques for monitoring brain activity.
  • Existing systems can be costly and lack portability, limiting widespread neuroscience research applications.

Purpose of the Study:

  • To design and implement a low-cost, portable, real-time, one-channel time-resolved diffuse optical spectroscopy system.
  • To evaluate the system's performance using phantom experiments.
  • To demonstrate enhanced sensitivity in detecting neural activity in the human cortex.

Main Methods:

  • Development of a novel one-channel time-resolved diffuse optical spectroscopy (DOS) system.
  • System calibration and performance validation using optical phantoms.

Related Experiment Videos

  • Preliminary human subject experiments to assess cortical neural activity detection.

    • Main Results:

    • The developed DOS system is low-cost, portable, and capable of real-time operation.
    • Phantom experiments confirmed the system's reliable performance.
    • Preliminary human data showed that employing late-arriving photons enhances sensitivity for detecting cortical neural activity.

    Conclusions:

    • A cost-effective and portable DOS system has been successfully developed for neuroscience.
    • The use of late-arriving photons is a promising strategy for improving the sensitivity of optical methods in brain activity monitoring.