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Reactive oxygen species activated nanoparticles with tumor acidity internalization for precise anticancer therapy
Hongzhang Deng1, Xuefei Zhao1, Liandong Deng2
1Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China.
Summary
Precise anticancer therapy is achieved using novel degradable nanoparticles (Pros-PDC) that release drugs in response to light. These nanoparticles offer controlled drug delivery, overcoming limitations of traditional cancer treatments.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Tumor cell and individual sensitivity to drug delivery systems varies, limiting therapeutic efficacy.
- Precise spatiotemporal control of drug delivery remains a major challenge in anticancer therapy.
Purpose of the Study:
- To develop a degradable nanoparticle system (Pros-PDC) for precise spatiotemporal anticancer drug delivery.
- To achieve enhanced drug internalization and controlled release triggered by external stimuli.
Main Methods:
- Preparation of degradable nanoparticles (Pros-PDC) loaded with doxorubicin (DOX) and IR780.
- Incorporation of a charge-conversional feature for extended circulation and enhanced cellular uptake.
- Integration of light-triggered reactive oxygen species (ROS) generation for ROS-responsive drug release.
Main Results:
- Pros-PDC nanoparticles demonstrated controlled, spatiotemporal drug release upon laser irradiation.
- The drug release profile was tunable based on the duration and timing of laser exposure.
- In vitro and in vivo studies confirmed the multifunctionality and controllability of the DOX and IR780 loaded Pros-PDC nanoparticles.
Conclusions:
- Pros-PDC nanoparticles represent a flexible and controllable drug delivery platform for precise anticancer therapy.
- The developed system effectively addresses the challenge of spatiotemporal drug delivery, enhancing therapeutic potential.