Reactive oxygen species activated nanoparticles with tumor acidity internalization for precise anticancer therapy

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Tumor cell and individual sensitivity to drug delivery systems varies, limiting therapeutic efficacy.
• Precise spatiotemporal control of drug delivery remains a major challenge in anticancer therapy.

Purpose of the Study:

• To develop a degradable nanoparticle system (Pros-PDC) for precise spatiotemporal anticancer drug delivery.
• To achieve enhanced drug internalization and controlled release triggered by external stimuli.

Main Methods:

• Preparation of degradable nanoparticles (Pros-PDC) loaded with doxorubicin (DOX) and IR780.
• Incorporation of a charge-conversional feature for extended circulation and enhanced cellular uptake.
• Integration of light-triggered reactive oxygen species (ROS) generation for ROS-responsive drug release.

Main Results:

• Pros-PDC nanoparticles demonstrated controlled, spatiotemporal drug release upon laser irradiation.
• The drug release profile was tunable based on the duration and timing of laser exposure.
• In vitro and in vivo studies confirmed the multifunctionality and controllability of the DOX and IR780 loaded Pros-PDC nanoparticles.

Conclusions:

• Pros-PDC nanoparticles represent a flexible and controllable drug delivery platform for precise anticancer therapy.
• The developed system effectively addresses the challenge of spatiotemporal drug delivery, enhancing therapeutic potential.