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Pediatric epilepsy - an Indian perspective
1Grant Medical College & JJ Group of Hospitals, PD Hinduja National Hospital and Bf Wadia Hospital for Children, Mumbai, India. vrajesh@vsnl.com.
Insights
Epilepsy prevalence in India mirrors developed nations, with neurocysticercosis (NCC) as a primary cause. Significant treatment gaps persist, highlighting a public health challenge for epilepsy management and care.
Area of Science:
- Neurology
- Public Health
- Epidemiology
Background:
- Epilepsy prevalence in India is comparable to developed countries.
- Neurocysticercosis (NCC) is a predominant etiological factor.
- A substantial treatment gap remains a significant public health concern.
Purpose of the Study:
- To review the prevalence and etiological factors of epilepsy in India.
- To highlight the challenges in epilepsy treatment and management.
- To detail prevalent etiologies like NCC and neonatal hypoglycemic brain injury.
Main Methods:
- Analysis of prevalence studies on epilepsy in India.
- Review of etiological factors, focusing on neurocysticercosis and neonatal hypoglycemic brain injury.
- Examination of risk factors for intractable epilepsy (IE).
Main Results:
- Epilepsy prevalence is similar to developed nations; NCC is a leading cause.
- Benign epilepsies and West syndrome appear underrepresented in classification studies.
- Risk factors for intractable epilepsy include early onset and neurodevelopmental issues; many cases are treatable.
Conclusions:
- Epilepsy management in India faces challenges due to prevalence and treatment gaps.
- Neurocysticercosis and neonatal brain injury are key etiologies requiring targeted interventions.
- Further research and improved therapeutic strategies are needed to address the epilepsy burden.
Abstract:
Prevalence studies from India suggest that epilepsy prevalence is similar to developed nations. Neurocysticercosis (NCC) predominates as an etiology. A large treatment gap is still a public health problem. Benign epilepsies and West syndrome appear to be underrepresented in studies on classification of seizures/syndromes. Febrile seizures prevalence in India is similar to other countries and appear to be as benign. Risk factors of intractable epilepsy (IE) in Indian studies include early age of onset, neurodevelopmental abnormalities and certain seizure types. Perinatal injuries underlie many IE. Many IE are not truly intractable and respond to simple therapeutic measures. The ketogenic diet and surgery are other methods now being used in Indian centers. Neurocysticercosis and neonatal hypoglycemic brain injury, two widely prevalent etiologies are reviewed in detail.
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