Related Experiment Videos
The asymmetric reduction of imidazolinones with trichlorosilane
Christian Wagner1, Andreas F Kotthaus, Stefan F Kirsch
1Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany. sfkirsch@uni-wuppertal.de.
Chemical Communications (Cambridge, England)
|April 8, 2017
Abstract:
It is shown how imidazolinones are reduced by trichlorosilane in a highly enantioselective fashion when treated with a novel Lewis base organocatalyst that is based on a 2,2'-bispyrrolidine core. Under mild reaction conditions and with low catalyst loading the hydrosilylation reaction provides a broad range of chiral imidazolidinones with various structural motifs including sterically demanding substituents, alkyls and aryls.