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Molecular imaging probes for multi-spectral optoacoustic tomography
Vipul Gujrati1, Anurag Mishra, Vasilis Ntziachristos
1Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg 85764, Germany. Vasilis.ntziachristos@helmholtz-muenchen.de.
Chemical Communications (Cambridge, England)
|April 8, 2017
Summary
Multi-Spectral Optoacoustic Tomography (MSOT) offers high-resolution, deep-tissue imaging by combining optical and acoustic methods. Advances in probes are enabling new non-invasive visualization of biological processes.
Area of Science:
- Biomedical Imaging
- Optical Physics
- Molecular Probes
Background:
- Multi-Spectral Optoacoustic Tomography (MSOT) integrates high-resolution imaging with optical imaging benefits.
- It exploits spectral detection of endogenous molecules and exogenous probes for deep tissue visualization.
- Recent technological advances enable real-time MSOT from microscopy to human imaging.
Purpose of the Study:
- To review recent progress in optoacoustic probes.
- To discuss applications and challenges for biological imaging using MSOT.
- To explore the prospects for clinical translation of MSOT probes.
Main Methods:
- Review of recent literature on optoacoustic probes.
- Analysis of technological advancements in MSOT.
- Discussion of probe optimization for optoacoustic signal generation.
Main Results:
- Emerging classes of probes offer new opportunities for in vivo visualization.
- MSOT enables non-invasive imaging of morphological and pathophysiological features.
- Real-time imaging capabilities have expanded MSOT applications.
Conclusions:
- Optoacoustic probes are crucial for advancing MSOT applications.
- Further development is needed to address challenges in biological imaging.
- Clinical translation of MSOT holds significant promise.
