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Related Experiment Videos

Amlodipine: The double edged sword.

Fatma Rabah1, Mohamed El-Naggari1, Dana Al-Nabhani1

  • 1Child Health Department, Sultan Qaboos University Hospital, Muscat, Oman.

Journal of Paediatrics and Child Health
|April 8, 2017
PubMed
Summary

Amlodipine, a common blood pressure medication, can cause swelling (oedema) in children. This case series highlights the importance of monitoring for this side effect in pediatric patients.

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Area of Science:

  • Pediatric Pharmacology
  • Cardiovascular Therapeutics

Background:

  • Amlodipine is a widely used antihypertensive medication in children due to its convenient once-daily dosing.
  • Common side effects include flushing, headache, and dizziness, with oedema reported less frequently in pediatric patients than adults.

Purpose of the Study:

  • To report four cases of generalised oedema in children treated with amlodipine.
  • To emphasize the need for vigilant monitoring of oedema in pediatric patients receiving amlodipine.

Main Methods:

  • Retrospective case series.
  • Inclusion of four pediatric patients presenting with amlodipine-related generalised oedema.

Main Results:

  • Four pediatric cases of generalised oedema associated with amlodipine use were identified.
  • Resolution of oedema upon discontinuation of amlodipine confirmed the drug as the causative agent.

Conclusions:

  • Amlodipine can cause generalised oedema in the paediatric population.
  • This series represents the largest documented cohort of amlodipine-induced generalised oedema in children, underscoring the importance of clinical surveillance.
Keywords:
amlodipineoedemapaediatric

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