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Renal function had an independent relationship with coronary artery calcification in Chinese elderly men
Shihui Fu1,2, Zhao Zhang2, Leiming Luo3
1Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
Insights
In Chinese elderly men without significant kidney damage, declining renal function is independently linked to coronary artery calcification (CAC). This suggests the association between kidney health and CAC begins early in kidney function decline.
Area of Science:
- Cardiology
- Nephrology
- Geriatrics
Background:
- Previous research on renal function and coronary artery calcification (CAC) primarily focused on pre-dialysis and dialysis patients.
- Limited studies have explored this relationship in elderly men without apparent renal impairment, particularly within the Chinese population.
Purpose of the Study:
- To investigate the association between renal function and CAC in Chinese elderly men with preserved kidney function.
- To determine if early-stage renal function decline is linked to coronary artery calcification in this demographic.
Main Methods:
- A cross-sectional study involving 105 male participants aged 60 years and above with a glomerular filtration rate (GFR) ≥ 45 ml/min/1.73 m².
- Coronary artery calcification (CAC) was assessed using high-definition computerized tomography (HDCT), a sensitive and accurate method for quantifying calcification.
Main Results:
- A significant inverse correlation was observed between GFR values and all measured CAC scores (Agatston, volume, and mass) (p < 0.05).
- Multivariate linear regression analysis confirmed that GFR was independently associated with all CAC scores (p < 0.05).
Conclusions:
- Renal function demonstrates an independent relationship with CAC in Chinese elderly men, as detected by HDCT.
- The findings indicate that the link between renal function and CAC emerges even at the early stages of renal function decline.
Background:
Although previous studies have analyzed the relationship between renal function and coronary artery calcification (CAC) in pre-dialysis and dialysis patients, limited studies have discussed the relationship between renal function and CAC in Chinese elderly men without obvious damage of renal function. The present study was designed to explore the relationship between renal function and CAC in Chinese elderly men without obvious damage of renal function.
Methods:
This cross-sectional study was carried out in 105 male participants older than 60 years with glomerular filtration rate (GFR) ≥ 45 ml/min/1.73 m2. CAC was detected by high-definition computerized tomography (HDCT), which is a highly sensitive technique for detecting the CAC and provides the most accurate CAC scores up to date.
Results:
Age was 72 ± 8.4 years on average and ranged from 60 to 89 years. Simple correlation analysis indicated that all kinds of CAC scores including the Agatston, volume and mass scores inversely correlated with GFR values (p < 0.05 for all). In multivariate linear regression analysis, GFR values were independently associated with all these CAC scores (p < 0.05 for all).
Conclusion:
Renal function had an independent relationship with CAC detected by HDCT in Chinese elderly men, demonstrating that the relationship between renal function and CAC started at the early stage of renal function decline.