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Epigenome-wide association studies for cancer biomarker discovery in circulating cell-free DNA: technical advances

Miljana Tanić1, Stephan Beck1

  • 1UCL Cancer Institute, University College London, London WC1E 6BT, UK.

Current Opinion in Genetics & Development
|April 10, 2017
PubMed

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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...