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Updated: Jul 10, 2026
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Factors Associated with Lower Extremity Dysmorphia Caused by Lower Extremity Lymphoedema
T Yamamoto1, N Yamamoto2, H Yoshimatsu3
1Department of Plastic Surgery, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan; Department of Plastic and Reconstructive Surgery, The University of Tokyo, Tokyo, Japan.
Summary
Indocyanine green (ICG) lymphography is useful for evaluating lower extremity dysmorphia (LED) in secondary lower extremity lymphedema (LEL). Higher ICG lymphography stages strongly correlate with LED, aiding in its assessment.
Area of Science:
- Vascular Medicine
- Diagnostic Imaging
- Lymphedema Research
Background:
- Indocyanine green (ICG) lymphography aids in early lymphedema diagnosis.
- Its utility in evaluating lower extremity dysmorphia (LED) secondary to lower extremity lymphedema (LEL) remains under-explored.
- This study investigates factors associated with LED in LEL patients.
Purpose of the Study:
- To identify independent factors associated with lower extremity dysmorphia (LED) in patients with secondary lower extremity lymphedema (LEL).
- To evaluate the role of indocyanine green (ICG) lymphography in assessing LED severity.
- To establish the diagnostic value of ICG lymphography for LED in LEL.
Main Methods:
- Retrospective observational study of 268 legs from 134 secondary LEL patients.
- Data collected included clinical demographics and ICG lymphography-based severity stage (leg dermal backflow [LDB] stage).
- Logistic regression analysis identified independent factors associated with LED (defined as LEL index ≥ 250).
Main Results:
- Lower extremity dysmorphia (LED) was present in 39.6% of legs.
- Higher LDB stages (III, IV, V) were strongly associated with LED.
- Increased age and higher body mass index showed inverse associations with LED.
Conclusions:
- Independent factors associated with LED in secondary LEL patients were identified.
- ICG lymphography-based severity stage demonstrated the strongest association with LED.
- ICG lymphography is a valuable tool for evaluating progressed LEL with LED.
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