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Treatment Strategies and Effectiveness in Lymphatic Malformations: A 10-Year Retrospective Study
M Shiraishi1,2, M Narushima1, C H Banda1,3
1Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Mie University, Tsu, Japan.
Lymphology
|May 13, 2025
Summary
Recurrence of lymphatic malformations (LMs) is common. Lymphaticovenular anastomosis (LVA) shows promise for LM treatment, while microcystic LMs are a risk factor for recurrence.
Area of Science:
- Vascular Surgery
- Pediatric Surgery
- Medical Research
Background:
- Lymphatic malformations (LMs) present a significant global challenge due to high recurrence rates post-treatment.
- Identifying factors influencing LM recurrence and comparing treatment efficacy are crucial for improving patient outcomes.
Purpose of the Study:
- To investigate risk factors associated with lymphatic malformation recurrence.
- To compare the effectiveness of surgical versus endovascular treatments for LMs.
Main Methods:
- A 10-year retrospective multi-center chart review (2009-2019) of patients treated for LMs.
- Data analysis included post-treatment size, symptoms, recurrence, and comparison of treatment modalities using stepwise multiple regression.
Main Results:
- Resection demonstrated the highest recurrence rate (36.4%, p=0.04).
- Lymphaticovenular anastomosis (LVA) showed excellent results in size reduction, symptom alleviation, and recurrence, though not statistically significant.
- Microcystic LM type was identified as an independent risk factor for recurrence.
Conclusions:
- Both surgical and endovascular approaches effectively improve LM size and symptoms.
- LVA appears to offer superior outcomes regarding recurrence compared to resection.
- Understanding risk factors like microcystic LM type can aid in treatment selection and progression prediction.
