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Incidence of Gastrointestinal Bleeding After Percutaneous Coronary Intervention: A Single Center Experience
1Penn State Hershey Medical Center, 500 University Drive, MC, Hershey, PA 17033, USA.
Insights
Gastrointestinal bleeding is a risk after percutaneous coronary intervention for heart attack. Previous bleeding and higher Killip class predict this complication, increasing mortality.
Area of Science:
- Cardiology
- Gastroenterology
- Interventional Cardiology
Background:
- Gastrointestinal (GI) bleeding is a known complication following percutaneous coronary intervention (PCI) in acute myocardial infarction (MI) patients.
- Identifying predictors and outcomes of GI bleeding is crucial for patient management.
Purpose of the Study:
- To determine predictors of GI bleeding in patients undergoing PCI for MI.
- To assess the impact of GI bleeding on mortality and morbidity post-PCI.
Main Methods:
- Retrospective analysis of 84 patients with ST-segment elevated myocardial infarction/Non ST-segment elevated myocardial infarction (STEMI/NSTEMI) undergoing primary PCI.
- Univariate analysis to identify factors associated with GI bleeding.
Main Results:
- GI bleeding occurred in 7.1% of patients.
- Previous GI bleeding and higher Killip classification at presentation were significantly associated with increased GI bleeding risk.
- Proton pump inhibitor use did not reduce GI bleeding risk.
- GI bleeding was linked to higher post-PCI mortality and morbidity.
Conclusions:
- Previous GI bleeding and higher Killip class are key predictors of GI bleeding in MI patients undergoing PCI.
- High-risk individuals can be identified upon presentation.
- GI bleeding significantly increases mortality and morbidity in this patient population.
Background:
Gastrointestinal (GI) bleeding is a hemorrhagic complication after percutaneous coronary intervention in patients with acute myocardial infarction. The purpose of the study is to determine predictors of GI bleeding and impact of GI bleeding on the patients undergoing percutaneous coronary intervention.
Methods:
GI bleeding occurred in 6 (7.1%) of 84 patients with STEMI/NSETMI (ST-segment elevated myocardial infarction/Non ST-segment elevated myocardial infarction) undergoing primary percutaneous coronary intervention.
Results:
Univariate analysis demonstrates that patients with GI bleeding had a significantly higher previous GI bleeding (16.66% vs. 8.6%, P < 0.001). Higher Killip classification at presentation was associated with higher incidence of GI bleeding (61% vs. 18%, P < 0.01). The use of proton pump inhibitors did not reduce the risk of GI bleeding. The GI bleeding in these patients was associated with higher mortality and morbidity in the post percutaneous coronary intervention period.
Conclusion:
Although, GI bleeding in patients with MI significantly increases mortality and morbidity, previous GI bleeding and higher Killip class are associated with higher incidence of GI bleeding. High-risk patients for GI bleeding can be identified at presentation.