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Related Experiment Videos

Biological changes and diseases in aged CBA/Ca mice.

E Beregi1, L Pénzes, O Regius

  • 1Gerontology Center, Semmelweis Medical University, Budapest, Hungary.

Comprehensive Gerontology. Section A, Clinical and Laboratory Sciences
|June 1, 1987
PubMed
Summary

Aging mice show decreased rectal temperature and altered protein metabolism, with significant changes in body weight and organ indices. Disease frequency increases with age, and spleen lymphocyte mitochondria exhibit age-related degenerative changes.

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Area of Science:

  • Gerontology
  • Biochemistry
  • Immunology

Background:

  • Aging is associated with physiological changes affecting metabolism and organ function.
  • Understanding age-related alterations is crucial for developing interventions to improve healthspan.
  • Mice models provide valuable insights into the aging process in mammals.

Purpose of the Study:

  • To investigate the effects of aging on cold adaptation, protein metabolism, body and organ weights, and disease incidence in mice.
  • To examine age-related mitochondrial changes in lymphocytes.
  • To establish a comprehensive profile of aging in inbred CBA/Ca male mice.

Main Methods:

  • Analysis of 661 untreated inbred CBA/Ca male mice across various age groups.
  • Measurement of rectal temperature following cold exposure.

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  • Assessment of apparent protein metabolism using 75Se-selenomethionine turnover.
  • Evaluation of body weight, organ weights, and organ indices.
  • Histopathological examination for disease frequency and mitochondrial morphology in spleen lymphocytes.

    • Main Results:

    • Aged mice exhibited a more pronounced decrease in rectal temperature upon cold exposure compared to young mice.
    • Biological half-life (T 1/2) for protein metabolism increased with age, decreasing in very old animals.
    • Significant age-related decreases in body weight, spleen index, and liver index were observed, while heart index increased.
    • Disease incidence peaked between 751-900 days, with hepatocellular carcinoma, amyloidosis, and pulmonary adenocarcinoma being most frequent.
    • Mitochondria in spleen lymphocytes showed degenerative changes, indicative of age-related biological alterations independent of specific diseases.

    Conclusions:

    • Aging in mice is characterized by impaired cold adaptation, altered protein metabolism, and significant physiological changes.
    • Age-related mitochondrial dysfunction in lymphocytes may serve as a biomarker for biological aging.
    • The study provides a detailed characterization of age-related changes and disease prevalence in a specific mouse strain.