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Propofol-induced acute pancreatitis.

J Csomor1, I Murínová2,3, K Broulíková1

  • 1Department of Internal Medicine, 1st Medical Faculty Charles University and Central Military Hospital Prague, Prague, Czech Republic.

Journal of Clinical Pharmacy and Therapeutics
|April 11, 2017
PubMed
Summary
This summary is machine-generated.

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A rare case of propofol-induced acute pancreatitis occurred in a patient after thyroid surgery. This is the first reported fatal case in an adult, highlighting propofol

Area of Science:

  • Anesthesiology
  • Gastroenterology
  • Pathology

Background:

  • Drug-induced acute pancreatitis is a rare complication, accounting for 0.5%-2% of all cases.
  • Propofol is recognized as a potential cause of acute pancreatitis, though such instances are exceptionally uncommon.

Observation:

  • A 57-year-old patient developed acute pancreatitis following a thyroidectomy.
  • Common causes of pancreatitis were ruled out, suggesting a drug etiology.
  • The pancreatitis was attributed to a single dose of propofol administered during surgery.

Findings:

  • The patient experienced acute necrotizing pancreatitis.
  • This case represents the first reported fatal instance of propofol-induced acute pancreatitis in an adult.
Keywords:
adverse drug reactiondrug-induced acute pancreatitispropofol

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Implications:

  • This case underscores the rare but severe potential adverse effects of propofol.
  • Highlights the importance of considering drug-induced pancreatitis in post-operative patients with unexplained pancreatitis.
  • Emphasizes the need for vigilance and further investigation into propofol's pancreatotoxicity.