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Rhodium-Catalyzed meta-C-H Functionalization of Arenes
Milan Bera1, Soumitra Agasti1, Rajdip Chowdhury1
1Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-, 400076, India.
Angewandte Chemie (International Ed. in English)
|April 11, 2017
Abstract:
Rhodium-catalyzed ortho-C-H functionalization is well known in the literature. Described herein is the Xphos-supported rhodium catalysis of meta-C-H olefination of benzylsulfonic acid and phenyl acetic acid frameworks with the assistance of a para-methoxy-substituted cyano phenol as the directing group. Complete mono-selectivity is observed for both scaffolds. A wide range of olefins and functional groups attached to arene are tolerated in this protocol.