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Altered B cell signalling in autoimmunity.

David J Rawlings1,2,3, Genita Metzler1,2, Michelle Wray-Dutra1,2

  • 1Seattle Children's Research Institute, 1900 9th Avenue, Seattle, Washington 98101, USA.

Nature Reviews. Immunology
|April 11, 2017
PubMed
Summary
This summary is machine-generated.

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Altered B cell signaling, not T cells, drives autoimmune diseases. Dysregulated B cell receptor (BCR) signals promote autoantibody production, predicting conditions like lupus and type 1 diabetes.

Area of Science:

  • Immunology
  • Autoimmunity Research
  • B cell Biology

Background:

  • Altered B cell-intrinsic signals via the B cell receptor (BCR) and co-receptors contribute to autoimmune pathogenesis.
  • These signals impact B cell selection and activation, influencing the development of autoreactive B cells.

Purpose of the Study:

  • To review the role of dysregulated B cell signaling in driving autoimmune diseases.
  • To highlight how BCR signaling alterations precede and predict disease onset.

Main Methods:

  • Review of recent scientific literature on B cell signaling in autoimmunity.
  • Analysis of the impact of BCR and co-receptor signaling on B cell repertoire selection and activation.

Main Results:

Related Experiment Videos

  • Dysregulated BCR signaling affects both naive B cell repertoire selection and activation responses.
  • High-affinity autoantibodies, driven by aberrant B cell signaling, predict autoimmune disease onset.
  • Autoimmune diseases can be primarily driven by B cell signaling, not solely by T cell activation.

    • Conclusions:

    • Aberrant B cell-intrinsic signals are a primary driver of human autoimmune diseases.
    • Understanding BCR signaling is crucial for developing targeted autoimmune therapies.
    • B cell-intrinsic signaling dysregulation offers a new perspective on autoimmune disease pathogenesis.