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Photo-cleavable analog of BAPTA for the fast and efficient release of Ca2
Mariia V Sutton1, Matthew McKinley, Revathy Kulasekharan
1Department of Chemistry, University of Georgia, Athens, GA 30677, USA. vpopik@uga.edu.
Chemical Communications (Cambridge, England)
|April 11, 2017
Abstract:
A new photocleavable analog of BAPTA chelating ligand has a high affinity towards Ca2+ ions (K = 2.5 × 106 M-1). The use of photolabile 3-(hydroxymethyl)-2-naphthol core in the design of photo-BAPTA allows for the efficient (Φ = 0. 63) and very fast (τ < 12 μs) release of Ca2+ ions upon 300 or 350 nm irradiation.