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Updated: Jul 23, 2026
09:33
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
Changes in the cell population in brain white matter in multiple system atrophy
Charlotte Havelund Nykjaer1, Tomasz Brudek1, Lisette Salvesen1,2
1Research Laboratory for Stereology and Neuroscience, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark.
Summary
Multiple system atrophy (MSA) involves significant white matter neuron loss and increased microglia. This study quanties glial cells in MSA brains, revealing microgliosis without astrogliosis.
Area of Science:
- Neuroscience
- Neuropathology
Background:
- Multiple system atrophy (MSA) is a progressive neurodegenerative disorder of unknown cause.
- Clinical features include autonomic failure, cerebellar ataxia, parkinsonism, and corticospinal dysfunction.
Purpose of the Study:
- To quantify neuronal and glial cell populations in the white matter of multiple system atrophy (MSA) brains.
- To investigate the extent of white matter involvement in MSA pathogenesis.
Main Methods:
- Stereology was used to count neurons, oligodendrocytes, astrocytes, and microglia in the white matter.
- Brains from 10 MSA patients and 11 age-matched controls were analyzed.
Main Results:
- A significant reduction (approximately 50%) in white matter interstitial neurons was observed in MSA patients compared to controls.
- MSA brains showed a significant increase (approximately 100%) in white matter microglia.
- No significant differences in the total numbers of white matter oligodendrocytes or astrocytes were found between groups.
Conclusions:
- Widespread microgliosis, but not astrogliosis, is present in the white matter of MSA patients.
- Significant oligodendrocyte degeneration was not detected, suggesting a complex role in MSA pathogenesis.
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