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Updated: Jan 11, 2026

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
Published on: April 17, 2017
[Chronic respiratory insufficiency in amyotrophic lateral sclerosis]
Anne Kathrine Staehr-Rye1,2, Simone Henriette Lisa Küchen1, Lisette Salvesen2,3
1Respirationscenter Øst, Afdeling for Anæstesi, Smerte og Respiratorisk Støtte, Københavns Universitetshospital - Rigshospitalet - Glostrup.
None:
Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by progressive loss of motor neurons in the brain and spinal cord. As the disease progresses, respiratory function becomes increasingly compromised. Supporting respiratory function is the treatment with the greatest potential impact on life expectancy and should align with the patient's wishes to ensure quality of life. Optimal secretion management is essential for effective non-invasive mechanical ventilation therapy, as argued in this review. Home invasive mechanical ventilation is reserved for a small subset of patients.
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