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Sharp wave ripples during learning stabilize the hippocampal spatial map.

Lisa Roux1, Bo Hu1, Ronny Eichler1

  • 1New York University Neuroscience Institute, New York University, New York, New York, USA.

Nature Neuroscience
|April 11, 2017
PubMed
Summary
This summary is machine-generated.

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Disrupting sharp wave-ripples (SPW-Rs) during learning prevents the brain from stabilizing spatial maps. This interference hinders the refinement of hippocampal place cell representations, impacting cognitive mapping.

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Systems Neuroscience

Background:

  • Stable hippocampal maps are crucial for cognitive environmental representation.
  • The mechanisms underlying the maintenance of these spatial maps remain largely unknown.
  • Sharp wave-ripples (SPW-Rs) are implicated in processing spatial information.

Purpose of the Study:

  • To investigate the role of SPW-R-associated neuronal activity in stabilizing hippocampal spatial maps.
  • To determine if disrupting activity during SPW-Rs affects the maintenance and refinement of place fields.
  • To test the hypothesis that SPW-R disruption impairs spatial representation.

Main Methods:

  • Mice learned daily sets of goal locations in a multiwell maze.
  • Optogenetic silencing of CA1 pyramidal neurons was triggered during SPW-Rs at goal locations using closed-loop detection.

Related Experiment Videos

  • Place cell activity and spatial information content were analyzed in silenced and control groups.

    • Main Results:

    • Optogenetic silencing of neurons during SPW-Rs caused place fields to remap.
    • Place fields of control cells maintained their location and showed increased spatial information.
    • SPW-R silencing did not alter neuronal firing rates or the proportion of place cells, but impaired map stabilization.

    Conclusions:

    • Interference with SPW-R-associated activity during learning prevents the stabilization and refinement of hippocampal maps.
    • SPW-Rs play a critical role in consolidating spatial representations.
    • Targeting SPW-R activity offers a potential avenue for understanding and manipulating hippocampal map formation.