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Selective particle and cell capture in a continuous flow using micro-vortex acoustic streaming.

David J Collins1, Bee Luan Khoo, Zhichao Ma

  • 1Pillar of Engineering Product Development, Singapore University of Technology and Design, Singapore 487372, Singapore. aiye@sutd.edu.sg.

Lab on a Chip
|April 11, 2017
PubMed
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Acoustic streaming generates powerful microscale vortices for precise particle and cell manipulation. This acoustofluidic technique enables selective capture of specific particles and cells from complex mixtures.

Area of Science:

  • Acoustofluidics
  • Microfluidics
  • Biotechnology

Background:

  • Acoustic streaming is a fluid dynamics phenomenon driven by acoustic waves.
  • It can generate strong rotational flow for microscale manipulation.
  • Conventional acoustofluidic systems often minimize acoustic streaming effects.

Purpose of the Study:

  • To maximize acoustic streaming in a microfluidic channel for particle and cell capture.
  • To investigate the formation of acoustic streaming vortices in a continuous flow system.
  • To demonstrate selective capture of microparticles and cells using these vortices.

Main Methods:

  • Utilized a high-frequency (381 MHz), narrow-beam focused surface acoustic wave.
  • Generated rapid fluid streaming and vortices spanning a 400 μm microfluidic channel.

Related Experiment Videos

  • Characterized forces for vortex formation in a combined streaming/lateral flow system.

    • Main Results:

    • Achieved fluid velocities orders of magnitude greater than lateral flow.
    • Successfully generated stable fluid vortices across the channel width.
    • Demonstrated selective capture of 2 μm particles from a mixed suspension.
    • Showcased selective capture of human breast adenocarcinoma cells (MDA-231) from red blood cells.

    Conclusions:

    • Acoustic streaming can be effectively maximized for microscale manipulation.
    • Acoustic streaming vortices provide a powerful tool for selective particle and cell separation.
    • This acoustofluidic approach offers a tunable, scalable, and pressure-source-free method for microscale fluid control.