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Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases

Manishabrata Bhowmick1,2, Dorota Tokmina-Roszyk3, Lillian Onwuha-Ekpete3

  • 1Torrey Pines Institute for Molecular Studies , 11350 SW Village Parkway, Port St. Lucie, Florida 34987, United States.

Journal of Medicinal Chemistry
|April 11, 2017
PubMed
Summary

Researchers enhanced triple-helical peptide inhibitors (THPIs) for greater stability and selectivity against matrix metalloproteinases (MMPs). These improved MMP inhibitors showed efficacy in mouse models for multiple sclerosis and sepsis, demonstrating therapeutic potential.

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