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Related Experiment Videos

Proteomics and irritable bowel syndrome.

Athanasios Tsigaridas1, Ioannis S Papanikolaou2, Anna Vaiopoulou3

  • 1a Gastroenterology Unit , Evangelismos Hospital , Athens , Greece.

Expert Review of Proteomics
|April 12, 2017
PubMed
Summary

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This review explores the use of proteomics in irritable bowel syndrome (IBS) research. Despite extensive studies, a sensitive and specific biomarker for IBS remains elusive.

Area of Science:

  • Gastroenterology
  • Proteomics
  • Biomarker Discovery

Background:

  • Irritable bowel syndrome (IBS) is a complex gastrointestinal disorder with poorly understood pathophysiology.
  • IBS presents with diverse symptoms and frequently overlaps with other conditions.
  • Current diagnostic criteria (Rome IV) classify IBS into four subtypes.

Purpose of the Study:

  • To review the application of proteomics in experimental studies related to IBS.
  • To highlight the role of proteomics in biomarker discovery for IBS.

Main Methods:

  • Literature review of proteomics studies in IBS research.
  • Analysis of the implementation of proteomic techniques in understanding IBS.

Main Results:

Keywords:
GeneticsIBSbiomarkerspathophysiologyproteomics

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  • Proteomics has been extensively utilized in IBS research for biomarker discovery.
  • Despite significant research efforts, a definitive, sensitive, and specific biomarker for IBS has not yet been identified.

Conclusions:

  • Proteomics offers valuable insights into IBS but has not yet yielded a clinically applicable biomarker.
  • Further research is needed to identify reliable biomarkers for IBS diagnosis and management.