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Related Experiment Videos

Oral sensory dysfunction following radiotherapy.

Shethal Bearelly1, Steven J Wang2, Steven W Cheung3

  • 1Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University, Nashville, Tennessee, U.S.A.

The Laryngoscope
|April 12, 2017
PubMed
Summary
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Radiation therapy significantly impairs oral tactile sensation, requiring higher forces for detection across all oral sites. This global sensory dysfunction, measured at 18.7 dB, affects patients long after treatment.

Area of Science:

  • Oral medicine
  • Neurology
  • Oncology

Background:

  • Radiation therapy (XRT) for head and neck cancers can affect oral structures.
  • Understanding the impact of XRT on oral tactile sensation is crucial for patient care and rehabilitation.

Purpose of the Study:

  • To quantitatively assess differences in oral tactile sensation between patients who received radiation therapy and healthy controls.

Main Methods:

  • A cross-sectional study compared 34 patients with a history of XRT to 23 healthy controls.
  • Oral tactile sensory thresholds were measured using Cheung-Bearelly monofilaments at four oral subsites.
  • Quantitative sensory testing assessed differences in force required for stimulus detection.

Main Results:

Keywords:
Cheung-Bearelly monofilamentsoral cavityradiotherapysensory threshold

Related Experiment Videos

  • Patients who received XRT required significantly higher forces to detect tactile stimuli at all four measured oral subsites (anterior tongue, buccal mucosa, posterior tongue, soft palate).
  • The XRT cohort demonstrated a 18.7 dB reduction in overall oral tactile sensation compared to controls.
  • P values were < .001 for all comparisons, indicating statistical significance.

Conclusions:

  • Radiation therapy leads to global tactile sensory dysfunction in the oral cavity and oropharynx.
  • This dysfunction is characterized by an increased force needed for tactile stimulus detection.
  • The magnitude of sensory impairment is quantified as 18.7 dB.