Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations of Sleep and Shift Work With Osteoarthritis Risk.

Arthritis care & research·2026
Same author

Environmental and genetic risk factors associated with total knee arthroplasty following cruciate ligament surgery.

The bone & joint journal·2024
Same author

Factors associated with genetic markers for rotator cuff disease in patients with atraumatic rotator cuff tears.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2023
Same author

Evaluation of Genetic and Nongenetic Risk Factors for Degenerative Cervical Myelopathy.

Spine·2023
Same author

Physical work exposure matrix for use in the UK Biobank.

Occupational medicine (Oxford, England)·2021
Same author

Identification of a Novel Genetic Marker for Risk of Degenerative Rotator Cuff Disease Surgery in the UK Biobank.

The Journal of bone and joint surgery. American volume·2021

Related Experiment Video

Updated: Jul 7, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Risk of Thyroid Cancer Among Solid Organ Transplant Recipients.

C M Kitahara1, E L Yanik1, P W Ladenson2

  • 1Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|April 12, 2017
PubMed
Summary

Solid organ transplant recipients show a 2.5-fold higher incidence of thyroid cancer. End-stage organ disease and prolonged dialysis are linked to increased thyroid cancer risk in these patients.

Keywords:
cancer/malignancy/neoplasia: risk factorsclinical research/practiceepidemiologyimmunosuppression/immune modulationkidney transplantation/nephrologyorgan transplantation in generaltranslational research/science

More Related Videos

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

Identification and Protection of the Recurrent Laryngeal Nerve during Transoral Robotic Thyroidectomy
05:25

Identification and Protection of the Recurrent Laryngeal Nerve during Transoral Robotic Thyroidectomy

Published on: October 24, 2025

Related Experiment Videos

Last Updated: Jul 7, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

Identification and Protection of the Recurrent Laryngeal Nerve during Transoral Robotic Thyroidectomy
05:25

Identification and Protection of the Recurrent Laryngeal Nerve during Transoral Robotic Thyroidectomy

Published on: October 24, 2025

Area of Science:

  • Oncology
  • Nephrology
  • Transplant Surgery

Background:

  • Solid organ transplant recipients (SOTRs) exhibit a higher risk of developing various cancers.
  • Thyroid cancer incidence in SOTRs has not been extensively studied, necessitating further investigation into associated risk factors.

Purpose of the Study:

  • To investigate the incidence of thyroid cancer in a large cohort of SOTRs.
  • To identify risk factors associated with thyroid cancer development and post-transplant outcomes in SOTRs.

Main Methods:

  • A cohort of 229,300 U.S. SOTRs (1987-2012) was analyzed using linked cancer registry data.
  • Incidence rate ratios (IRRs) and hazard ratios (HRs) were calculated, adjusting for multiple demographic and clinical variables.

Main Results:

  • Thyroid cancer incidence was 2.50-fold higher in SOTRs compared to the general population.
  • Kidney transplant recipients had the highest incidence. Specific indications for transplantation (cholestatic liver disease, hypertensive nephrosclerosis) and longer dialysis duration were associated with elevated risk.
  • Post-transplant thyroid cancer diagnosis correlated with a modestly increased risk of death (HR = 1.33).

Conclusions:

  • End-stage organ disease and extended dialysis duration may contribute to the elevated thyroid cancer incidence observed in transplant recipients.
  • These findings highlight the need for increased surveillance for thyroid cancer in SOTRs, particularly those with specific underlying conditions and longer dialysis histories.