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Investigation and Optimization of the Effect of Polymers on Drug Release of Norfloxacin from Floating Tablets

Dipak D Gadade1, Kalpana Sarda1, Sadhana R Shahi2

  • 1Shri Bhagwan College of Pharmacy, Aurangabad, India.

Polimery W Medycynie
|April 12, 2017
PubMed
Abstract

Insights

This study optimized norfloxacin floating tablets using release-retarding polymers, achieving 12-hour drug release. Batch-F4 demonstrated optimal performance, complying with USP limits and showing good floating properties.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Polymer Science

Background:

  • Norfloxacin, a fluoroquinolone antibiotic, is used for various infections but requires frequent dosing due to its short half-life.
  • Release-retarding polymers offer a strategy to control norfloxacin release and improve therapeutic efficacy.
  • Floating tablet technology can enhance drug retention time in the gastrointestinal tract.

Purpose of the Study:

  • To investigate the impact of release-retarding polymers on norfloxacin release from floating tablets.
  • To optimize the formulation of norfloxacin-loaded floating tablets for sustained drug delivery.
  • To evaluate the pharmaceutical properties and drug release kinetics of the developed floating tablets.

Main Methods:

  • Norfloxacin and hydroxypropyl methylcellulose (HPMC K100M) were used in tablet formulations.
  • Tablets were prepared using the direct compression method.
  • In-vitro drug release, floating properties, and drug release kinetics were evaluated using specialized software.

Main Results:

  • All tested formulations (F1-F9) exhibited drug release for up to 12 hours with satisfactory floating characteristics.
  • Batch-F4 formulation met USP dissolution limits and displayed minimal floating lag time.
  • Drug release kinetics analysis indicated that Batch-F4 best fits the Peppas model (R²=0.9921, release exponent=0.6892).

Conclusions:

  • The floating tablets release norfloxacin via a combined diffusion and erosion mechanism.
  • Formulation variables, specifically HPMC K100M and sodium alginate concentrations, significantly influence drug release.
  • Batch-F4 represents a promising formulation for sustained norfloxacin delivery.
Keywords:
drug dissolutionfloating drug delivery systemsgastroretentive drug delivery systemsnorfloxacin

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