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Synthesis of AHMOD-containing aminolipopeptides, unique bioactive peptaibiotics
Louise A Stubbing1, Iman Kavianinia, Margaret A Brimble
1School of Chemical Sciences, The University of Auckland, 23 Symonds St, Auckland, New Zealand. m.brimble@auckland.ac.nz.
Organic & Biomolecular Chemistry
|April 12, 2017
Abstract:
An interesting family of bioactive aminolipopeptides contain the unusual building block 2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid (AHMOD). This building block has presented a significant challenge to synthesis of this family of aminolipopeptides due to the sensitive β-hydroxyketone motif present. The discovery and identification, syntheses, and eventual incorporation of synthetically challenging AHMOD into selected aminolipopeptides is described herein.