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Related Experiment Videos

Online Flowing Colloidosomes for Sequential Multi-analyte High-Throughput SERS Analysis.

Gia Chuong Phan-Quang1, Elizabeth Hui Zi Wee1, Fengling Yang1

  • 1Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore.

Angewandte Chemie (International Ed. in English)
|April 12, 2017
PubMed
Summary

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This summary is machine-generated.

This study introduces a novel microfluidic system using 3D plasmonic colloidosomes for rapid, reproducible online Surface-Enhanced Raman Spectroscopy (SERS) detection, preventing contamination and enabling high-throughput analysis.

Area of Science:

  • Nanotechnology
  • Analytical Chemistry
  • Spectroscopy

Background:

  • Surface-Enhanced Raman Spectroscopy (SERS) offers high sensitivity for molecular detection.
  • Existing online SERS platforms suffer from poor signal reproducibility and cross-contamination.
  • 3D plasmonic colloidosomes exhibit superior SERS sensing capabilities.

Purpose of the Study:

  • To develop an online SERS detection system using 3D plasmonic colloidosomes.
  • To overcome limitations of existing online SERS platforms, specifically signal reproducibility and contamination.
  • To enable rapid, continuous, and accurate sample analysis.

Main Methods:

  • Integration of 3D plasmonic colloidosomes within a microfluidic channel.
  • Development of a flow system for online SERS detection.
Keywords:
SERScolloidosomesmicrofluidicsmultiplex assaysoptical detection

Related Experiment Videos

  • Implementation of isolated colloidosomes to prevent inter-sample contamination.

    • Main Results:

    • Achieved rapid and continuous online detection of 20 samples in under 5 minutes.
    • Demonstrated excellent signal reproducibility and accurate quantification over five orders of magnitude.
    • Enabled high-resolution multiplex detection with preserved analyte signals in mixtures.

    Conclusions:

    • The developed microfluidic SERS system with 3D plasmonic colloidosomes provides a robust solution for online analysis.
    • The system effectively prevents cross-contamination, ensuring accurate quantification and multiplex detection.
    • This high-throughput platform facilitates rapid identification and quantification of diverse samples.