Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genome Architecture from a Different Angle.

Elizabeth H Finn1, Tom Misteli1

  • 1National Cancer Institute, NIH, Bethesda, MD 20892, USA.

Developmental Cell
|April 12, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome reorganization and its functional impact during breast cancer progression.

eLife·2026
Same author

Connecting multiway enhancer-promoter interactions to changes in gene expression in cancer.

bioRxiv : the preprint server for biology·2026
Same author

Orderly mitosis shapes interphase genome architecture.

eLife·2026
Same author

TAD boundaries and gene activity are uncoupled.

eLife·2026
Same author

Acute degron-mediated RUNX1 loss reprograms enhancer activity to epigenetically drive epithelial destabilization and initiate cancer hallmarks.

bioRxiv : the preprint server for biology·2026
Same author

Protocol to measure transcriptional bursting of endogenous genes using high-throughput RNA-FISH.

STAR protocols·2026
Same journal

AXIN1 and AXIN2 regulate the WNT-signaling landscape to promote distinct mesoderm programs.

Developmental cell·2026
Same journal

ARID1A terminates gastric regeneration to prevent cancer.

Developmental cell·2026
Same journal

Myc sustains sex-biased organ zonation in the Drosophila intestine.

Developmental cell·2026
Same journal

Two parallel neuronal circuits involving electrical synapse and DAF-7/TGF-β signaling regulate muscle autophagy in C. elegans.

Developmental cell·2026
Same journal

Menstruation: Once unspoken but now uncovered, one cell type at a time.

Developmental cell·2026
Same journal

The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair.

Developmental cell·2026
See all related articles

Researchers developed genome architecture mapping, an orthogonal technique to validate 3D genome mapping methods. This innovation addresses the need for independent validation in genome architecture studies.

Area of Science:

  • Genomics
  • Molecular Biology
  • Biotechnology

Background:

  • Advanced techniques like nuclear proximity ligation and high-throughput sequencing have improved genome architecture studies.
  • A lack of independent validation methods has hindered the assessment of these new techniques.

Purpose of the Study:

  • To introduce an orthogonal technique for validating genome architecture mapping methods.
  • To provide a reliable method for mapping the 3D organization of genomes.

Main Methods:

  • Genome architecture mapping (GAM) was developed as an orthogonal validation technique.
  • The method combines nuclear proximity ligation and high-throughput sequencing principles.

Main Results:

  • Genome architecture mapping provides an independent means to validate existing 3D genome mapping techniques.

Related Experiment Videos

  • The study successfully demonstrated the utility of GAM for studying genome organization.

    • Conclusions:

    • Genome architecture mapping is a valuable new tool for the field of 3D genomics.
    • This technique enhances the reliability and accuracy of genome architecture studies.