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Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review.
Vanessa Ramos Pires Dinarte1, Anemari Ramos Dinarte Dos Santos2, Luiza Ferreira de Araújo3
1Escola de Medicina de Marília, Departamento de Otorrinolaringologia, Divisão de Otorrinolaringologia, Marília, SP, Brazil.
Brazilian Journal of Otorhinolaryngology
|April 13, 2017
Summary
Genetic studies reveal key insights into chronic rhinosinusitis with nasal polyps (CRSwNP). Polymorphisms in genes like MMP-9 and LTC4S are linked to CRSwNP risk, especially with allergies and asthma.
Area of Science:
- Genetics
- Immunology
- Otolaryngology
Background:
- Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex disease influenced by genetic and environmental factors.
- Understanding the genetic underpinnings of CRSwNP is crucial for advancing treatment strategies.
Purpose of the Study:
- To review the significance of genetic studies in CRSwNP.
- To highlight the challenges in understanding the genetic basis of CRSwNP.
Main Methods:
- Systematic review of studies published between January 2005 and January 2015.
- Searched PubMed/Medline and Periódicos CAPES for articles on polymorphisms, rhinosinusitis, and polyps.
Main Results:
- MMP-9 and MMP-2 polymorphisms associated with CRSwNP in some studies.
- Evidence links LTC4S, NOS2A, PTGDR, MET, COX-2, OSF-2, and LF polymorphisms to CRSwNP risk, particularly with allergic rhinitis and asthma.
- Associations varied, with some polymorphisms not linked to recurrent nasal polyps.
Conclusions:
- Genetic research in CRSwNP holds promise for elucidating its complex pathophysiology.
- Multiple genetic factors likely contribute to the development of CRSwNP.