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Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...

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Hyperbaric oxygen preconditioning improves postoperative cognitive dysfunction by reducing oxidant stress and

Zhi-Xin Gao1, Jin Rao1, Yuan-Hai Li1

  • 1Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.

Neural Regeneration Research
|April 13, 2017
PubMed
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Hyperbaric oxygen preconditioning shows promise in preventing postoperative cognitive dysfunction. This method may alleviate symptoms by activating the body's natural antioxidant and anti-inflammatory defenses.

Keywords:
anti-inflammationantioxidantsbrain injurycognitive dysfunctionhyperbaric oxygenationinflammationnerve regenerationneural regenerationoxidant stresspost-operationpreconditioningprotectionreactive oxygen species

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Area of Science:

  • Neuroscience
  • Anesthesiology
  • Public Health

Background:

  • Postoperative cognitive dysfunction (POCD) is a significant concern with limited effective treatments.
  • Hyperbaric oxygen (HBO) preconditioning demonstrates organ-protective effects, including in the brain.
  • HBO preconditioning is emerging as a potential strategy for POCD prevention.

Purpose of the Study:

  • To review the application and definition of hyperbaric oxygen preconditioning.
  • To explore the mechanisms and impact of postoperative cognitive dysfunction.
  • To summarize the effects of hyperbaric oxygen preconditioning on POCD.

Main Methods:

  • Literature review focusing on hyperbaric oxygen preconditioning and postoperative cognitive dysfunction.
  • Analysis of neuroprotective mechanisms.
  • Synthesis of current research findings.

Main Results:

  • Hyperbaric oxygen preconditioning has shown promising results in preventing and alleviating POCD.
  • The neuroprotective mechanisms are complex and not fully elucidated.
  • HBO preconditioning appears to stimulate endogenous antioxidant and anti-inflammatory systems.

Conclusions:

  • Hyperbaric oxygen preconditioning is an effective and feasible approach for managing POCD.
  • Further research is needed to fully understand its complex mechanisms of action.
  • HBO preconditioning offers a potential therapeutic strategy for improving cognitive outcomes after surgery.