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KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number
Marjorie Fournier1, László Tora2
1Sir William Dunn School of Pathology, University of Oxford , Oxford, UK.
Molecular & Cellular Oncology
|April 13, 2017
Abstract:
We have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-like kinase 4 (PLK4) maintains correct centrosome number in human cells, therefore contributing to the maintenance of genome stability.1.