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Parathyroid Hormone-Related Peptide: A Novel Endocrine Cardioprotective "Conditioning Mimetic"
Tanuka Datta1, Karin Przyklenk2,3,4, Nabanita S Datta2,5
11 Department of Internal Medicine, George Washington University, Washington, DC, USA.
Journal of Cardiovascular Pharmacology and Therapeutics
|April 14, 2017
Abstract:
An as-yet limited body of evidence suggests that calcium-regulating endocrine hormones-in particular, parathyroid hormone-related peptide (PTHrP)-may have unappreciated cardioprotective effects. The current review focuses on the concept that PTHrP may, via modulation of classic cardioprotective signaling pathways, provide a novel strategy to attenuate myocardial ischemia-reperfusion injury.