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No-carrier-added radiobromination via cuprous chloride-assisted nucleophilic aromatic bromodeiodination
S M Moerlein1, D R Hwang, M J Welch
1Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
|January 1, 1988
Abstract:
Cuprous chloride-assisted aromatic bromodeiodination was investigated as a regioselective no-carrier-added labelling technique. Using 77Br-, CuCl and simple iodinated aromatic substrates in DMSO, radiochemical yields ranged from 60 to 90% after 30 min at 135 degrees C. The methodology described here holds potential for the convenient labelling of radiopharmaceuticals with 75Br, 76Br or 77Br.