Related Experiment Video
Updated: Jul 26, 2026

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
Published on: May 15, 2013
A comparison of the 'Maxima' and the modified Ayre's T-piece breathing systems in spontaneously breathing cats
1Division of Companion Animals, Department of Clinical Veterinary Science, Langford House, Langford, Bristol, UK.
Objective:
To compare the fresh gas flow requirements of the 'Maxima' and Jackson-Rees modified Ayre's T-piece (JRMATP) in spontaneously breathing anaesthetized in cats.
Study Design:
Prospective randomized clinical study.
Animals Or Sample Population:
Fifteen adult cats (6 male, 9 female, 3.1 ± 0.4 kg [ x¯ ± SD]).
Materials & Methods:
After pre-anaesthetic medication with acepromazine and pethidine, anaesthesia was induced using thiopentone and the trachea was intubated with a cuffed endotracheal tube. This was attached to either a 'Maxima' or a JRMATP breathing system; allocation was randomized. Anaesthesia was maintained with halothane delivered in a 1 : 1 oxygen : nitrous oxide mixture. Initial total fresh gas flow (FGF) was set at 600 mL kg-1 min-1. After 20 minutes, FGF was reduced in increments of 200 mL min-1 until rebreathing (inspired CO2 concentration >0.2%) occurred. At this point, FGF was increased to 600 mL kg-1 and the process was repeated with the other breathing system. The respiratory rate and airway pressure at the endotracheal tube connector were monitored throughout anaesthesia.
Results:
The mean fresh gas flow that prevented rebreathing with the Maxima system (164 ± 39 mL kg-1) was significantly less (p < 0.0001) than that required in the modified T-piece (455 ± 0.77 mL kg-1). Respiratory rates and airway pressures at the endotracheal tube connector were not significantly affected by breathing system employed.
Conclusions:
In terms of the gas flow requirements that prevent rebreathing, the 'Maxima' breathing system is more efficient than the modified Ayre's T-piece in spontaneously breathing cats anaesthetised with halothane.
Related Concept Videos
Mechanism of Breathing I: Inspiration
The respiratory system, an essential network for breathing, comprises the conducting and respiratory zones, each playing a crucial role in the overall process of respiration. Let us explore the detailed mechanism of inspiration, or inhalation, which is the first phase of the respiratory cycle.
Pathway of Air during Inspiration
During inspiration, air enters our body through the nose or mouth and moves through the conducting zone,...
Mechanism of Breathing II: Expiration
Expiration, or exhaling, is a complex physiological process that begins as the inspiratory muscles begin to relax. This relaxation triggers a series of events that epitomize the efficiency of the respiratory system.
Mechanism of Expiration:
Mechanism of Breathing III: The Accessory Muscles
The respiratory system is a complex network that relies on primary respiratory muscles like the diaphragm, but also involves accessory muscles to enhance lung expansion and airflow during both inhalation and exhalation.
Enhancing Inhalation with Accessory Muscles:
Accessory muscles such as the sternocleidomastoid, scalene, intercostal, and abdominal muscles are crucial when additional respiratory effort is required, such as during deep...
Respiratory Capacities
One key metric is the Inspiratory Capacity (IC), which represents the maximum amount of air that can be inhaled with full effort. IC is calculated by summing the tidal volume and inspiratory reserve volume, typically ranging from 2.4 to 3.6 liters.
The Functional Residual Capacity (FRC) represents the air in the...
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Cardiopulmonary Resuscitation II: ACLS Airway Management

