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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

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Pathophysiology of Aortic Valve Stenosis: Is It Both Fibrocalcific and Sex Specific?

Yoginee Sritharen1, Maurice Enriquez-Sarano2, Hartzell V Schaff1

  • 1Department of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota.

Physiology (Bethesda, Md.)
|April 14, 2017
PubMed

Insights

Aortic valve stenosis research lags behind other heart conditions. This review covers clinical problems, underlying biology, and sex hormone links in fibrocalcific aortic valve stenosis.

Area of Science:

  • Cardiovascular Biology
  • Translational Medicine
  • Valvular Heart Disease

Background:

  • Aortic valve stenosis (AVS) pathogenesis is less understood than atherosclerosis or heart failure.
  • Fibrocalcific AVS affects both men and women, presenting significant clinical challenges.
  • Limited progress in identifying effective therapeutic targets for AVS.

Purpose of the Study:

  • To review the most clinically relevant issues in fibrocalcific aortic valve stenosis.
  • To discuss the fundamental biological mechanisms of aortic valve calcification and fibrosis.
  • To identify molecular targets at the intersection of AVS and sex hormone signaling.

Main Methods:

  • Literature review focusing on fibrocalcific aortic valve stenosis.
  • Analysis of fundamental biological processes in valve calcification and fibrosis.
  • Exploration of molecular links between sex hormones and AVS.

Main Results:

  • Significant knowledge gap exists in AVS fundamental biology and therapeutics.
  • Fibrocalcific AVS involves complex calcification and fibrosis pathways.
  • Sex hormone signaling pathways represent potential therapeutic targets.

Conclusions:

  • Further research into AVS biology is crucial for therapeutic development.
  • Understanding the role of sex hormones may unlock new treatment strategies for AVS.
  • Bridging the knowledge gap in AVS is essential for improving patient outcomes.

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