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Related Experiment Videos

Microbiotal-Host Interactions and Hypertension.

Sarah Galla1, Saroj Chakraborty1, Blair Mell1

  • 1Physiological Genomics Laboratory, Center for Hypertension and Personalized Medicine, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio; and.

Physiology (Bethesda, Md.)
|April 14, 2017
PubMed
Summary
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The microbiome, or microbial metagenome, significantly influences blood pressure (BP) regulation. Modifying the microbiome offers a novel approach for managing hypertension, complementing host genetics.

Area of Science:

  • Microbiology
  • Genetics
  • Physiology

Background:

  • Hypertension (elevated blood pressure) is a multifactorial condition influenced by host genetics and environmental factors.
  • Emerging evidence suggests the microbiome, the collective genomes of indigenous microorganisms, also plays a critical role in blood pressure regulation.
  • The microbiome is a dynamic entity, alterable by diet and transplantation, unlike the relatively static host genome.

Purpose of the Study:

  • To review current literature on the microbiome's role in blood pressure regulation.
  • To highlight the potential of the microbiome as a therapeutic target for hypertension.
  • To emphasize the importance of studying the host-microbiota interaction within the holobiont context for understanding blood pressure.

Main Methods:

Related Experiment Videos

  • Literature review of studies investigating the relationship between the microbiome and blood pressure.
  • Analysis of evidence supporting the microbiome's influence on blood pressure.
  • Exploration of the concept of the holobiont in the context of blood pressure regulation.

    • Main Results:

    • The microbiome is an understudied but significant determinant of blood pressure.
    • The microbiome's plasticity allows for potential therapeutic interventions for hypertension.
    • Host-microbiota interactions within the holobiont are crucial for blood pressure homeostasis.

    Conclusions:

    • The microbiome is a key factor in blood pressure regulation, alongside host genetics.
    • Targeting the microbiome presents a promising avenue for novel hypertension management strategies.
    • Further research into the holobiont is essential for a comprehensive understanding of blood pressure control.