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Updated: Aug 1, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Leukocytoclastic vasculitis drug reaction to certolizumab pegol
Meghan Woody1, Donald Warren1, Laura Speck1
1University of Texas Dell Medical School, Austin, Texas (Woody); Baylor Scott & White, Marble Falls, Texas (Warren); and Westlake Dermatology, Austin, Texas (Speck, Jackson).
Abstract:
Tumor necrosis factor (TNF)-alpha antagonists are a common treatment modality for autoimmune disorders, but their use can be associated with many side effects, including various dermatologic conditions. Certolizumab pegol, a newer TNF antagonist that lacks the Fc portion of the IgG antibody, has recently been approved to treat psoriatic arthritis, rheumatoid arthritis, and Crohn's disease. Though other TNF antagonists have been associated with leukocytoclastic vasculitis, this finding has not yet been reported with certolizumab pegol. We present a case report of leukocytoclastic vasculitis caused by certolizumab pegol.
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